The Landscapes Within includes three sets of three 1.5 x 3’ vertically stacked, light-illuminated, hand-etched, glass panels that visualize microscopic cellular processes within the human body. Each visualization can be viewed in-the-round.
This illumination highlights the innate immune system, bringing attention to the primary level of human defense against infectious agents and foreign bodies. Etched in the glass are alveolar macrophages (AM), found in the lungs, protecting one of the body’s most accessible entry points from the range of elements inhaled. When visualizing the internal processes at work, one can appreciate how amazing this basic immune function is and how powerful AMs are in targeting and eliminating harmful invaders; easily taken for granted unless compromised. One can also be thoughtful about how human impact and lifestyle choices affect immune responses. Unsurprisingly, studies have shown air quality and environmental factors affect AM function. For example, tobacco smoke, ozone, and aerosols decrease AM phagocytosis function (Migliaccio & Holian, 2010).
This illumination conveys the transition of cells lining the esophagus, or esophageal epithelium, in response to chronic acid reflux. The condition, called Barret’s Esophagus, is when the lining of the esophagus begins to resemble that of the intestine, which can be a precursor to esophageal cancer. GERD, or gastroesophageal reflux disease, is a condition leading to Barret’s. The cells that transition from normal to abnormal are overlaid in the glass panels; blue represents normal epithelium, dark red shows gastric acid, and orange is abnormal metaplastic columnar tissue. Epithelial cells are protective and plastic by nature; normal tissue lining is often restored with healthy habits. This work is meant to promote regular monitoring of the esophagus and healthy lifestyle choices, such as a diet that reduces the intake of fatty foods, caffeine, and alcohol, which can help control acid reflux, as does avoiding overeating and smoking.
This piece shows a potential site for adult neurogenesis in the hippocampus of the brain, generating new neurons, strengthening neural pathways, and improving memory, especially when linked to exercise and positive affirmation. Located in the medial temporal lobe, this area is connected to memory, learning, and emotion. The effects of post-traumatic stress disorder have been shown to degrade this part of the brain and affect memory retention. On the other hand, positive emotions can promote creativity, curiosity, and problem solving; we are more willing to explore content and be open-minded in a positive mindset, all the while improving memory retention.